I have noticed some difference between budeprion xl and wellbutrin xl as well. I keep thinking that it's all in my head and wishing that it was since there is a big difference in price between the two. Hello Melissalives, Interactions between your selected drugs. bupropion ↔ citalopram Applies to: Wellbutrin (bupropion), Celexa (citalopram) Talk to your doctor before using buPROPion together with citalopram. Wellbutrin CAN be helpful even when people have previously had a good response to an SSRI (Zoloft, Prozac, Paxil, Lexapro, etc.). It does have some serotinergic effect, as those meds do, but also works on a different neurotransmitter and may give you more energy. I only take 75 mg of regular Wellbutrin. I can fall asleep but usually up at 4 or 5 and can't get back to sleep! So tired during the day. Wellbutrin SR vs Wellbutrin XL. Feeling sad is natural for most people especially when there is good reason to be. Some things might not go the way we originally planned them. Find patient medical information for Wellbutrin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Wellbutrin is the brand name for bupropion, a prescription drug that's used to treat depression. It's also used to treat seasonal affective disorder (SAD), a type of depression that usually. Cymbalta (duloxetine) and Wellbutrin (bupropion) are antidepressants used for treating depression. Cymbalta is also used to treat anxiety disorder, and pain associated with diabetic peripheral neuropathy or fibromyalgia. Find patient medical information for Wellbutrin XL Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. I am trying Wellbutrin, and in 3 days, I had a terrible taste in my mouth. It has been over 8 weeks now, and it has not subsided. What other similar drugs are there to try???.